The cyclin E–CDK2 complex was thought to be an essential regulator of the mitotic cell cycle. Surprisingly, disabling the critical genes in the mouse has fewer effects than anticipated.
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Roberts, J., Sherr, C. Bared essentials of CDK2 and cyclin E. Nat Genet 35, 8–9 (2003). https://doi.org/10.1038/ng1234
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DOI: https://doi.org/10.1038/ng1234
