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Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene

Nature Genetics volume 34, pages 261–262 (2003)Cite this article

Abstract

MicroRNAs (miRNAs) are an abundant class of RNAs that are ∼21–25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

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Figure 1: Several microRNA genes map within an imprinted locus on mouse distal 12 chromosome/human 14q32.
Figure 2: miR-127 and miR-136, two miRNAs expressed from the maternal chromosome, are antisense to Rtl1, a retrotransposon-like gene expressed only from the paternally inherited chromosome.

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Acknowledgements

This work was supported by grants from the Toulouse Génopole, the Programme Interdisciplinaire du Centre National de la Recherche Scientifique Dynamique et Réactivité des Assemblages Biologiques and La Ligue contre le Cancer/Comité de Haute-Garonne (to J.C.) and by laboratory funds from the Centre National de la Recherche Scientifique and Université Paul-Sabatier, Toulouse (to J.-P.B.). Work in M.P.'s laboratory was supported by the Deutsche Forschungs Gemeinschaft. N.Y. is supported by a BBSRC studentship and S.-P. L. by a scholarship from the Taiwanese government. H.S. is supported by a PhD fellowship Allocation de Moniteur Normalien (Ministère de l'Education Nationale, de la Recherche et de la Technologie).

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Authors and Affiliations

  1. LBME, Centre National de la Recherche Scientifique (UMR 5099), IFR 109, Université P. Sabatier, 118 route de Narbonne, Toulouse, 31062, Cedex, France

    Hervé Seitz, Jean-Pierre Bachellerie & Jérôme Cavaillé

  2. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK

    Neil Youngson, Shau-Ping Lin & Anne C Ferguson-Smith

  3. Universität des Saarlandes, FR Genetik, Postfach 151150, Saarbrücken, D-66041, Germany

    Simone Dalbert & Martina Paulsen

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  1. Hervé Seitz
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  2. Neil Youngson
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  4. Simone Dalbert
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  5. Martina Paulsen
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  6. Jean-Pierre Bachellerie
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  7. Anne C Ferguson-Smith
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Correspondence to Jérôme Cavaillé.

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Seitz, H., Youngson, N., Lin, SP. et al. Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet 34, 261–262 (2003). https://doi.org/10.1038/ng1171

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