Trudy F. C. Mackay is in the Department of Genetics, Campus Box 7614, North Carolina State University, Raleigh, North Carolina 27612, USA. trudy_mackay@ncsu.edu
One challenge in modern biology is to understand the detailed genetic basis of variation for quantitative traits, including complex behaviors. A new study shows that historical recombination in outbred strains combined with functional complementation tests can identify pleiotropic genes with small effects on naturally occurring variation for anxiety-related behaviors in mice.
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