Nature Genetics
29, 247 - 248 (2001)
doi:10.1038/ng1101-247
Pharmacogenetics: more than skin deepHoward L. McLeod
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. hmcleod@im.wustl.edu
It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes. Whereas ethnic and geographic differences are commonly used to classify drug response, new results show that more accurate and robust genetic clusters—identified by genotyping a modest number of neutral markers—can be inferred with no prior knowledge of ethnicity. Such an approach may eventually become a part of drug evaluation and clinical practice.
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