Nature Genetics32, 562 - 563 (2002)
Published online: 4 November 2002; | doi:10.1038/ng1043
Of man in mice
Jyoti N. Athanikar, Tammy A. Morrish
& John V. Moran
Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0618.
Correspondence should be addressed to John V. Moran moranj@umich.edu
L1 retrotransposition is ongoing, and has dramatically affected the evolution and structure of mammalian genomes. Despite their impact on the genome, little is known about when, where or how frequently L1s retrotranspose in vivo. The establishment of a mouse model of human L1 retrotransposition is a major step toward answering these questions.
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