Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rhythm is not enough

MAGEL2 is located in a cluster of imprinted genes on human chromosome 15 that is implicated in Prader-Willi syndrome (PWS). A new study shows that mice deficient for this gene show altered behavioral rhythmicity that resembles some features of PWS.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: An autonomous, self-sustained oscillator acts as the core of the biological clock.

Kim Caesar

References

  1. Kozlov, S.V. et al. Nat. Genet. 39, 1266–1272 (2007).

    Article  CAS  PubMed  Google Scholar 

  2. Panda, S. et al. Cell 109, 307–320 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Moore, T. & Haig, D. Trends Genet. 7, 45–49 (1991).

    Article  CAS  PubMed  Google Scholar 

  4. Rapkins, R.W. et al. PLoS Genet. 2, e182 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gabriel, J.M. et al. Proc. Natl. Acad. Sci. USA 96, 9258–9263 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. Yang, T. et al. Nat. Genet. 19, 25–31 (1998).

    Article  CAS  PubMed  Google Scholar 

  7. Runte, M. et al. Hum. Mol. Genet. 10, 2687–2700 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Gallagher, R.C., Pils, B., Albalwi, M. & Francke, U. Am. J. Hum. Genet. 71, 669–678 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cavaillé, J. et al. Proc. Natl. Acad. Sci. USA 97, 14311–14316 (2000).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Horsthemke, B. Rhythm is not enough. Nat Genet 39, 1190–1191 (2007). https://doi.org/10.1038/ng1007-1190

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1007-1190

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing