Gijs R. van den Brink is in the department of Experimental Internal Medicine of the Academic Medical Center, Amsterdam, the Netherlands. g.r.vandenbrink@amc.uva.nl
Studies of inherited cancer syndromes have implicated numerous signaling pathways in colorectal carcinogenesis, but the relationship between these signaling pathways remains poorly understood. Now, a new mouse model of juvenile polyposis syndrome identifies a molecular mechanism for clonal epithelial cell expansion and links several pathways with an established role in polyposis.
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