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EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

Nature Genetics volume 4, pages 341–345 (1993)Cite this article

Abstract

The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant melanoma of soft parts have been characterized and shown to form, in four cases studied, hybrid transcripts. The deduced chimaeric protein encoded by the der(22) chromosome consists of the N–terminal domain of EWS linked to the bZIP domain of ATF–1, a transcription factor which may normally be regulated by cAMP. ATF–1 has not previously been implicated in oncogenesis. EWS was first identified as forming a hybrid transcript in Ewing's sarcoma, which links its N–terminal domain to the DNA binding domain of the FLI–1 gene. Thus the oncogenic conversion of EWS follows a common scheme of activation, exchanging its putative RNA binding domain with different DNA binding domains that appear to be tumour–specific.

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Authors and Affiliations

  1. Laboratory de Tumour Genetics, INSERM CJF 9201, Institut Curie, 26 rue d'Ulm, 75231, Paris, Cedex 05, France

    Jessica Zucman, Olivier Delattre, Chantal Desmaze, Alain Aurias & Gilles Thomas

  2. Department of Pathology, University of Southern California, Medical Center, 2011 Zonal Ave., Los Angeles, California, 90033, USA

    Alan L. Epstein

  3. Department of Odontology, Gothenburg University, POB 33070, S-400330, Götebotg, Sweden

    Goran Stenman

  4. Department of Medical Genetics, University Hospital Ghent, B-9000, Ghent, Belgium

    Frank Speleman

  5. Department of Histopathology, St. Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK

    Christopher D. M. Fletchers

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Zucman, J., Delattre, O., Desmaze, C. et al. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 4, 341–345 (1993). https://doi.org/10.1038/ng0893-341

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