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Guilt beyond a reasonable doubt

Genome-wide association studies, exemplified by the Wellcome Trust Case Control Consortium and follow-up studies, have identified dozens of common variants robustly associated with common diseases, providing new clues about genetic architecture in humans. Finding all such loci, and fully defining genotype-phenotype correlation, will be a key to translating initial clues into pathophysiological understanding and clinical prediction.

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References

  1. Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  2. Parkes, M. et al. Nat. Genet. 39, 830–832 (2007).

    Article  CAS  Google Scholar 

  3. Todd, J. et al. Nat. Genet. 39, 857–864 (2007)

    Article  CAS  Google Scholar 

  4. Zeggini, E. et al. Science 316, 1336–1341 (2007).

    Article  CAS  Google Scholar 

  5. NCI-NHGRI Working Group on Replication in Association Studies et al. Nature 447, 655–660 (2007).

  6. Duerr, R.H. et al. Science 314, 1461–1463 (2006).

    Article  CAS  Google Scholar 

  7. Cargill, M. et al. Am. J. Hum. Genet. 80, 273–290 (2007).

    Article  CAS  Google Scholar 

  8. Easton, D.F. et al. Nature, advance online publication 27 May 2007 (doi:10.1038/nature05887).

    Article  CAS  Google Scholar 

  9. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research et al. Science 316, 1331–1336 (2007).

  10. Scott, L.J. et al. Science 316, 1341–1345 (2007).

    Article  CAS  Google Scholar 

  11. McPherson, R. et al. Science, 316, 1488–1491 (2007).

    Article  CAS  Google Scholar 

  12. Helgadottir, A. et al. Science, 316, 1491–1493 (2007).

    Article  CAS  Google Scholar 

  13. Haiman, C. et al. Nat. Genet. 39, 638–644 (2007).

    Article  CAS  Google Scholar 

  14. Kotowski, I.K. et al. Am. J. Hum. Genet. 78, 410–422 (2006).

    Article  CAS  Google Scholar 

  15. Purcell, S. et al. Bioinformatics 19, 149–150 (2003).

    Article  CAS  Google Scholar 

Download references

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Altshuler, D., Daly, M. Guilt beyond a reasonable doubt. Nat Genet 39, 813–815 (2007). https://doi.org/10.1038/ng0707-813

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