A.D.A. is in the Department of Biochemistry and C.M.K. is in the Department of Biostatistics and Medical Informatics at the University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. attie@biochem.wisc.edu or kendzior@biostat.wisc.edu
Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein- co-activator-1 (PGC-1) seems to be in charge of this orchestrated change in gene expression.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
at the crossroads of type 2 diabetes
co-activator-1
(PGC-1
-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
