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Another piece of the autism puzzle

Nature Genetics volume 42, pages 478–479 (2010)Cite this article

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A new study has identified rare de novo mutations in SHANK2 in individuals with autism and/or mental retardation. SHANK2 encodes a scaffolding protein present in excitatory synapses. This finding sheds some light on the pathophysiology of social and cognitive disability.

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Figure 1: Molecular network at the synapse includes molecules implicated in social disability.

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Authors and Affiliations

  1. Departments of Child Psychiatry, Matthew W. State is at the Program on Neurogenetics and the, Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Matthew W State

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  1. Matthew W State
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Correspondence to Matthew W State.

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State, M. Another piece of the autism puzzle. Nat Genet 42, 478–479 (2010). https://doi.org/10.1038/ng0610-478

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