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Nature Genetics 39, 707 - 708 (2007)
doi:10.1038/ng0607-707
Scarce but scary
Anja-Katrin Bielinsky1
- Anja-Katrin Bielinsky is in the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. e-mail: bieli003@umn.edu
Abstract
Spontaneous, replication-induced DNA breaks are likely to be a primary source of chromosomal rearrangements typical of cancer, but it is unknown how often these breaks occur in normal cells. A new study suggests that they are exceedingly rare but probably up to 100-fold more potent in causing genome instability than previously estimated.
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