Noora Kotaja and Paolo Sassone-Corsi are at the Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France. paolosc@igbmc.u-strasbg.fr
The molecular mechanisms that regulate the balance between differentiation and self-renewal in spermatogonial stem cells are elusive. Two studies now show that the transcriptional repressor Plzf is an essential regulator of spermatogonial stem cell maintenance.
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