In a new study, the presence of a CpG island transgene protects neighboring sequence from DNA methylation during development leading to an open chromatin state that persists in the adult animal. This study suggests the importance of DNA methylation in setting up the epigenome.
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Park, KY., Pfeifer, K. Epigenetic interplay. Nat Genet 34, 126–128 (2003). https://doi.org/10.1038/ng0603-126
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DOI: https://doi.org/10.1038/ng0603-126
