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Coevolution in the tumor microenvironment

The progression of carcinomas to high-grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma undergo genetic alterations during this progression, a new study now provides evidence that strongly contradicts this theory of stromal cell coevolution.

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Figure 1: Islands of neoplastic epithelial cells (light blue nuclei) are surrounded by a myofibroblast-rich stroma (dark brown).

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Weinberg, R. Coevolution in the tumor microenvironment. Nat Genet 40, 494–495 (2008). https://doi.org/10.1038/ng0508-494

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