Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MicroRNAs as tumor suppressors

Nature Genetics volume 39, pages 582–583 (2007)Cite this article

Human cancers are characterized by widespread reduction in microRNA gene expression, but what role does this have in the pathobiology of the disease? A new study proves that reduction in microRNA expression does indeed promote tumorigenesis, changing the way we think about cancer.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The RNases Drosha and Dicer process the miRNA primary transcript and generate the ∼22-nucleotide mature miRNA species.

Kim Caesar

References

  1. Wightman, B., Ha, I. & Ruvkun, G. Cell 75, 855–862 (1993).

    Article  CAS  PubMed  Google Scholar 

  2. Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).

    Article  CAS  PubMed  Google Scholar 

  3. Esquela-Kerscher, A. & Slack, F.J. Nat. Rev. Cancer 6, 259–269 (2006).

    Article  CAS  PubMed  Google Scholar 

  4. Kumar, M.S. Nat. Genet. 39, 673–677 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Tagawa, H. & Seto, M. Leukemia 19, 2013–2016 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. He, L. et al. Nature 435, 828–833 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lu, J. et al. Nature 435, 834–838 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Gaur, A. et al. Cancer Res. 67, 2456–2468 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Karube, Y. et al. Cancer Sci. 96, 111–115 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. Johnson, S.M. et al. Cell 120, 635–647 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Mayr, C., Hemann, M.T. & Bartel, D.P. Science 315, 1576–1579 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Thomson, J.M. et al. Genes Dev. 20, 2202–2207 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Wulczyn, F.G. et al. FASEB J. 21, 415–426 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scott M. Hammond is in the Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA. Hammond@med.unc.edu,

    Scott M Hammond

Authors
  1. Scott M Hammond
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hammond, S. MicroRNAs as tumor suppressors. Nat Genet 39, 582–583 (2007). https://doi.org/10.1038/ng0507-582

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0507-582

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing