1. John S. Witte is in the Department of Epidemiology and Biostatistics and the Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143-0794, USA. e-mail: jwitte@ucsf.edu

Abstract

Three new reports leverage genome-wide studies to localize and replicate multiple independent variants strongly associated with prostate cancer on chromosome 8q24. These findings provide a significant advance toward deciphering the genetic basis of this disease, although further work is needed to clarify the biological mechanisms underlying these associations.

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