Nature Genetics
- 38, 504 - 506 (2006)
doi:10.1038/ng0506-504
A broad band of silenceJustin S Smith & Joseph F Costello
Justin S. Smith and Joseph F. Costello are in the Department of Neurological Surgery, University of California, San Francisco, California, 94143, USA. jcostello@cc.ucsf.edu
Aberrant methylation of a CpG island in cancer is thought to silence a single gene but not its neighbors. A new study in colon cancer shows that transcriptional silencing can also be unexpectedly diffuse, encompassing all the genes over the 4 Mb of chromosome band 2q14.2, marked by archipelagos of methylated islands and uniform heterochromatin modification.
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