Nature Genetics 38, 403 - 404 (2006)
doi:10.1038/ng0406-403
A key stone cop regulates oxalate homeostasisRobert Kleta
Robert Kleta is at the Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20982, USA. kletar@mail.nih.gov
A new study shows that Slc26a6-null mice manifest calcium-oxalate nephrolithiasis accompanied by enhanced net intestinal oxalate absorption. These findings point to a critical role for Slc26a6 in gastrointestinal oxalate secretion and suggest a genetic explanation for a common form of renal stone disease in humans.
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