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Clonal diversity in tumor progression

A new study uses an evolutionary approach to characterize the diversity within populations of cells in Barrett's esophagus lesions. Greater genetic clonal diversity is found to be associated with higher risks for transformation.

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Figure 1: Diversity as a key parameter driving transformation.

References

  1. Hahn, W.C. & Weinberg, R.A. N. Engl. J. Med. 347, 1593–1603 (2002).

    Article  CAS  Google Scholar 

  2. Nowell, P.C. Science 194, 23–28 (1976).

    Article  CAS  Google Scholar 

  3. Maley, C.C. et al. Nat. Genet. 38, 468–473 (2006).

    Article  CAS  Google Scholar 

  4. Gould, S.J. & Eldredge, N. Nature 366, 223–227 (1993).

    Article  CAS  Google Scholar 

  5. Paulson, T.G. & Reid, B.J. Cancer Cell 6, 11–16 (2004).

    Article  CAS  Google Scholar 

  6. Barrett, M.T. et al. Nat. Genet. 22, 106–109 (1999).

    Article  CAS  Google Scholar 

  7. Tomlinson, I. & Bodmer, W. Nat. Med. 5, 11–12 (1999).

    Article  CAS  Google Scholar 

  8. Calabrese, P., Tavaré, S. & Shibata, D. Am. J. Pathol. 164, 1337–1346 (2004).

    Article  Google Scholar 

  9. Vogelstein, B. & Kinzler, K.W. Proc. Natl. Acad. Sci. USA 96, 9236–9241 (1999).

    Article  CAS  Google Scholar 

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Shibata, D. Clonal diversity in tumor progression. Nat Genet 38, 402–403 (2006). https://doi.org/10.1038/ng0406-402

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