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Disentangling the roots of inherited hair disorders

Rare syndromes offer unique opportunities to gain insight into central physiological processes. By deciphering the genetic basis of two rare inherited diseases, two studies identify a key role for P2Y5, a G protein–coupled receptor, in hair follicle development.

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Figure 1: Deciphering the pathogenesis of inherited nonsyndromic forms of alopecias reveals pathways regulating hair development.

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Sprecher, E. Disentangling the roots of inherited hair disorders. Nat Genet 40, 265–266 (2008). https://doi.org/10.1038/ng0308-265

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