News and Views
Nature Genetics 40, 132 - 134 (2008)
doi:10.1038/ng0208-132
Hypoxic reprogramming
Daniel P Kelly1
- Daniel P. Kelly is in the Center for Cardiovascular Research, Departments of Medicine, Developmental Biology, and Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: dkelly@wustl.edu
Abstract
Many organisms have an amazing capacity to adapt to conditions of low oxygen, but the cellular mechanisms of this are poorly understood. A new study in mice has unveiled a molecular trigger that initiates a cascade of events to reprogram cellular oxygen requirements.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolismNature Genetics Article (01 Feb 2008)
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer modelCancer Gene Therapy Original Article
See all 3 matches for Research