Nature Genetics 38, 137 - 138 (2006)
doi:10.1038/ng0206-137
Anthrax target in macrophages unveiledThomas H Bugge
& Stephen H Leppla
Thomas H. Bugge is in the Proteases and Tissue Remodeling Unit, National Institute of Dental and Craniofacial Research (NIDCR), US National Institutes of Health (NIH), and Stephen H. Leppla is in the Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, US NIH, Bethesda, Maryland, USA. sleppla@niaid.nih.gov
Anthrax lethal toxin lyses macrophages derived from certain inbred mice but not others, forming the basis of a bioassay widely used in the development of antibodies and drugs to treat anthrax. A new study identifies two genes essential for this lysis, revealing potential links between toxin-induced proteolysis and cellular killing. REFERENCES
-
Ezzell, J.W.
,
Ivins, B.E.
&
Leppla, S.H.
Infect. Immun. 45, 761–767 (1984). | PubMed | ISI | ChemPort |
-
Friedlander, A.M.
J. Biol. Chem. 261, 7123–7126 (1986). | PubMed | ISI | ChemPort |
-
Duesbery, N.S.
et al. Science 280, 734–737 (1998). | Article | PubMed | ISI | ChemPort |
-
Vitale, G.
et al. Biochem. Biophys. Res. Commun. 248, 706–711 (1998). | Article | PubMed | ISI | ChemPort |
-
Leppla, S.H.
in Bacterial Protein Toxins (Springer, Berlin, 2000).
-
Boyden, E.D.
&
Dietrich, W.F.
Nat. Genet. 38, 240–244 (2006). | Article |
-
Roberts, J.E.
,
Watters, J.W.
,
Ballard, J.D.
&
Dietrich, W.F.
Mol. Microbiol. 29, 581–591 (1998). | Article | PubMed | ISI | ChemPort |
-
Watters, J.W.
,
Dewar, K.
,
Lehoczky, J.
,
Boyartchuk, V.
&
Dietrich, W.F.
Curr. Biol. 11, 1503–1511 (2001). | Article | PubMed | ISI | ChemPort |
-
Tschopp, J.
,
Martinon, F.
&
Burns, K.
Nat. Rev. Mol. Cell Biol. 4, 95–104 (2003). | Article | PubMed | ISI | ChemPort |
-
Chamaillard, M.
,
Girardin, S.E.
,
Viala, J.
&
Philpott, D.J.
Cell. Microbiol. 5, 581–592 (2003). | Article | PubMed | ISI | ChemPort |
-
Ting, J.P.
&
Davis, B.K.
Annu. Rev. Immunol. 23, 387–414 (2005). | Article | PubMed | ISI | ChemPort |
-
Martinon, F.
,
Burns, K.
&
Tschopp, J.
Mol. Cell 10, 417–426 (2002). | Article | PubMed | ISI | ChemPort |
-
Burns, K.
,
Martinon, F.
&
Tschopp, J.
Curr. Opin. Immunol. 15, 26–30 (2003). | Article | PubMed | ISI | ChemPort |
-
Moayeri, M.
,
Martinez, N.W.
,
Wiggins, J.
,
Young, H.A.
&
Leppla, S.H.
Infect. Immun. 72, 4439–4447 (2004). | Article | PubMed | ISI | ChemPort |
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