U470, INSERM, Centre de Biochimie, Universite de Nice, Parc Valrose, 06108 Nice, France. minoo@unice.fr
In 1994, Ralph Brinster and colleagues demonstrated that male germ cells could repopulate a mouse testis into which they had been transplanted and could then continue and complete their differentiation. They now report production of transgenic progeny after retroviral infection of germline stem cells in culture prior to their transfer to a recipient male. This achievement may lead to new developments in the manipulation and study of mammalian genomes.
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