News and Views
Nature Genetics 39, 10 - 11 (2007)
doi:10.1038/ng0107-10
Chaotic license for genetic instability and cancer
Anindya Dutta1
- Anindya Dutta is at the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA. e-mail: ad8q@virginia.edu
Abstract
Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.
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