Letter abstract
Nature Genetics 39, 1384 - 1389 (2007)
Published online: 28 October 2007 | doi:10.1038/ng.2007.19
Recurrent DNA copy number variation in the laboratory mouse
Chris M Egan1, Srinath Sridhar2, Michael Wigler1 & Ira M Hall1
Different species, populations and individuals vary considerably in the copy number of discrete segments of their genomes. The manner and frequency with which these genetic differences arise over generational time is not well understood. Taking advantage of divergence among lineages sharing a recent common ancestry, we have conducted a genome-wide analysis of spontaneous copy number variation (CNV) in the laboratory mouse. We used high-resolution microarrays to identify 38 CNVs among 14 colonies of the C57BL/6 strain spanning 
967 generations of inbreeding, and we examined these loci in 12 additional strains. It is clear from our results that many CNVs arise through a highly nonrandom process: 18 of 38 were the product of recurrent mutation, and rates of change varied roughly four orders of magnitude across different loci. Recurrent CNVs are found throughout the genome, affect 43 genes and fluctuate in copy number over mere hundreds of generations, observations that raise questions about their contribution to natural variation.
- Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
- Computer Science Department, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Correspondence to: Ira M Hall1 e-mail: hall@cshl.edu
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