News and Views
Nature Chemical Biology 2, 659 - 660 (2006)
doi:10.1038/nchembio1206-659
A sweet success for substrate engineering
Byron R Griffith1 & Jon S Thorson1
- Byron R. Griffith and Jon S. Thorson are in the Pharmaceutical Sciences Division of the School of Pharmacy, University of Wisconsin, Madison, 53705, USA. e-mail: jsthorson@pharmacy.wisc.edu
Abstract
Chemically synthesizing complex oligosaccharides remains a significant challenge. Through the addition of hydrophobic appendages to 'unnatural' substrates, some oligosaccharide-forming glycosyltransferases can direct the formation of distinct sugar linkages while maintaining stereoselectivity.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysisNature Chemical Biology Letter (01 Dec 2006)
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysisNature Chemical Biology Letter
