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Nitrated cyclic GMP as a new cellular signal

Nature Chemical Biology volume 3, pages 687–688 (2007)Cite this article

Nitric oxide–mediated production of cyclic guanosine 3′,5′-monophosphate (cGMP) is a crucial signal transduction pathway that controls a wide array of biological functions. A new layer of complexity in mammalian cell regulation is revealed by the discovery of a redox-active nitrated cGMP derivative with the ability to post-translationally modify protein thiol residues by S-guanylation.

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Figure 1: Simplified scheme of the NO-cGMP signal transduction pathway in relation to the formation and biological activity of the new messenger molecule 8-nitro-cGMP.

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  1. Martin Feelisch is at the Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. mf@warwick.ac.uk,

    Martin Feelisch

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  1. Martin Feelisch
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Feelisch, M. Nitrated cyclic GMP as a new cellular signal. Nat Chem Biol 3, 687–688 (2007). https://doi.org/10.1038/nchembio1107-687

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