Protein nitrosation is an important signaling mechanism in vivo; however, mechanisms for selective nitric oxide modification of cysteines have not been described. Thioredoxin is now shown to rapidly and site-specifically catalyze S-nitrosation of an active site cysteine of caspase-3.
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Tannenbaum, S., Kim, JE. Controlled S-nitrosation. Nat Chem Biol 1, 126–127 (2005). https://doi.org/10.1038/nchembio0805-126
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DOI: https://doi.org/10.1038/nchembio0805-126