1. Lance Wells is in the Complex Carbohydrate Research Center and the Department of Biochemistry and Molecular Biology, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602-4172, USA. e-mail: lwells@ccrc.uga.edu

Abstract

In addition to expanding the chemical tools for exploring O-GlcNAc protein modifications, an innovative chemical biology approach has yielded new insights into the dynamic nature of this post-translational modification in the rodent brain.

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