News and Views
Nature Chemical Biology 4, 269 - 270 (2008)
doi:10.1038/nchembio0508-269
-Mannoside hydrolysis goes by boat
Monica M Palcic1
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Monica M. Palcic is in the Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby, Copenhagen, Denmark.
e-mail: monica@crc.dk
Abstract
Enzymatic hydrolysis of 
-mannosides was predicted to occur via an unusual boat transition state conformation. Structural and biochemical studies on transition state mimics of a retaining -mannosidase now provide evidence for the predicted B2,5 transition state conformation.
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