Square-planar, four-coordinate metal complexes strip peptides from the binding site of MHC class II molecules. Removal of peptides derived from self-antigens could prevent class II–dependent activation of self-reactive T cells in autoimmune diseases such as rheumatoid arthritis.
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Roche, P. Gold-plating MHC class II molecules. Nat Chem Biol 2, 178–179 (2006). https://doi.org/10.1038/nchembio0406-178
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DOI: https://doi.org/10.1038/nchembio0406-178
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nanoGold and µGold inhibit autoimmune inflammation: a review
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