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Nature Chemical Biology 2, 67 - 68 (2006)
doi:10.1038/nchembio0206-67
Sweet insights into learning and memory
Gerald W Hart1
- Gerald W. Hart is in the Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA. e-mail: gwhart@jhmi.edu
Abstract
Studies have linked the Fuc
(1-2)Gal modification of neuronal glycoproteins to cognitive processes such as learning and memory. The identification of synapsins Ia and Ib as the main Fuc(1-2)Gal-bearing neuronal proteins not only suggests previously unknown molecular mechanisms of neuronal plasticity but also indicates the existence of previously unknown glycosylation pathways in neurons.
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