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Principles of a switch

Lambda's 'genetic switch' responds in a dramatic all-or-none fashion to an environmental signal, activating transcription of certain genes as it turns off others. The switch illustrates principal features of many biological regulatory processes.

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Figure 1: The lambda switch.
Figure 2: Examples of regulatory protein actions in eukaryotes.

References

  1. Davidson, E.H. The Regulatory Genome: Gene Regulatory Networks in Development and Evolution (Academic Press, Burlington, Massachusetts, USA, 2006).

    Google Scholar 

  2. Ptashne, M. A Genetic Switch (Third Edition): Phage Lambda Revisited (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2004).

    Google Scholar 

  3. Wenick, A.S. & Hobert, O. Dev. Cell 6, 757–770 (2004).

    Article  CAS  Google Scholar 

  4. Hong, J.W., Hendrix, D.A., Papatsenko, D. & Levine, M.S. Proc. Natl. Acad. Sci. USA 105, 20072–20076 (2008).

    Article  CAS  Google Scholar 

  5. Ptashne, M. & Gann, A. Genes and Signals (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2002).

    Google Scholar 

  6. Schubert, R.A., Dodd, I.B., Egan, J.B. & Shearwin, K.E. Genes Dev. 21, 2461–2472 (2007).

    Article  CAS  Google Scholar 

  7. Ptashne, M. Curr. Biol. 17, R740–R741 (2007).

    Article  CAS  Google Scholar 

  8. Struhl, K. Cell 98, 1–4 (1999).

    Article  CAS  Google Scholar 

  9. Floer, M. et al. Cell 141, 407–418 (2010).

    Article  CAS  Google Scholar 

  10. Wang, X., Bryant, G.O., Floer, M., Spagna, D. & Ptashne, M. Nat. Struct. Mol. Biol. 18, 507–509 (2011).

    Article  Google Scholar 

  11. Bai, L., Ondracka, A. & Cross, F.R. Mol. Cell 42, 465–476 (2011).

    Article  CAS  Google Scholar 

  12. Ferrell, J.E. Jr. Curr. Opin. Cell Biol. 14, 140–148 (2002).

    Article  CAS  Google Scholar 

  13. Dodd, I.B. et al. Genes Dev. 18, 344–354 (2004).

    Article  CAS  Google Scholar 

  14. Ptashne, M. Curr. Biol. 17, R233–R236 (2007).

    Article  CAS  Google Scholar 

  15. Gomes, J.E., Corado, M.S. & Schweisguth, F. PLoS ONE 4, e4485 (2009).

    Article  Google Scholar 

  16. Yamanaka, S. & Blau, H.M. Nature 465, 704–712 (2010).

    Article  CAS  Google Scholar 

  17. Graf, T. & Enver, T. Nature 462, 587–594 (2009).

    Article  CAS  Google Scholar 

  18. Hobert, O. Proc. Natl. Acad. Sci. USA 105, 20067–20071 (2008).

    Article  CAS  Google Scholar 

  19. Sekido, R. & Lovell-Badge, R. Nature 453, 930–934 (2008).

    Article  CAS  Google Scholar 

  20. Etchberger, J.F., Flowers, E.B., Poole, R.J., Bashllari, E. & Hobert, O. Development 136, 147–160 (2009).

    Article  CAS  Google Scholar 

  21. Blau, H.M., Chiu, C.P. & Webster, C. Cell 32, 1171–1180 (1983).

    Article  CAS  Google Scholar 

  22. Gurdon J.B. Dev. Biol. 4, 256–73. (1962)

    Article  CAS  Google Scholar 

  23. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  24. Ptashne, M. Curr. Biol. 19, R234–R241 (2009).

    Article  CAS  Google Scholar 

  25. Coudreuse, D. & Nurse, P. Nature 468, 1074–1079 (2010).

    Article  CAS  Google Scholar 

  26. Moazed, D. Nature 457, 413–420 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Mark Ptashne.

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Ptashne, M. Principles of a switch. Nat Chem Biol 7, 484–487 (2011). https://doi.org/10.1038/nchembio.611

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