The susceptibility of organisms to chemical perturbation differs as a result of defenses that limit the permeation of small molecules. Screening for permeation, rather than bioactivity, to identify a priori organism-specific chemical space offers an intriguing approach to phenotypic assays and potentially addresses some fundamental challenges in drug discovery.
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Hopkins, A., Bickerton, G. Know your chemical space. Nat Chem Biol 6, 482–483 (2010). https://doi.org/10.1038/nchembio.395
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DOI: https://doi.org/10.1038/nchembio.395
