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G1 cyclins protect pluripotency

Nature Cell Biology volume 19, pages 149–150 (2017)Cite this article

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G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

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Figure 1: G1 cyclins and cyclin-dependent kinases in cell cycle progression and maintenance of pluripotency in mESCs.

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Authors and Affiliations

  1. Departments of Pediatrics and Genetics, Julia Arand and Julien Sage are at the Stanford University Medical Center, Stanford Medical School, SIM1 Building, 265 Campus Drive, Stanford, California 94305, USA,

    Julia Arand & Julien Sage

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  1. Julia Arand
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  2. Julien Sage
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Correspondence to Julien Sage.

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The authors declare no competing financial interests.

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Arand, J., Sage, J. G1 cyclins protect pluripotency. Nat Cell Biol 19, 149–150 (2017). https://doi.org/10.1038/ncb3480

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