News and Views
Nature Cell Biology 9, 1125 - 1127 (2007)
doi:10.1038/ncb1007-1125
Shaping membranes into autophagosomes
Muriel Mari1 & Fulvio Reggiori1
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Muriel Mari and Fulvio Reggiori are at the Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
e-mail: F.Reggiori@umcutrecht.nl
Abstract
The class III phosphatidylinositol 3-kinase (PI(3)KC3) is part of a key complex regulating autophagy. How this complex mechanistically contributes to autophagosome formation remains largely unknown. The BAR-domain-containing protein Bif-1/endophilin B1, commonly associated with the control of membrane curvature, has been identified as a new interacting partner for PI(3)KC3, suggesting the complex plays an active part in the regulation of membrane dynamics during autophagy.
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