1. Shigeo Ohno is at the Department of Molecular Biology, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan. e-mail: ohnos@med.yokohama-cu.ac.jp

Abstract

Specification of the axon and dendrites is a critical step in the development of a neuron and requires the asymmetric organization of the cell. A possible link between the extrinsic and intrinsic pathways that drive axon specification has been made with the finding that Dishevelled acts downstream of Wnt5a to activate the PAR6–aPKC–PAR3 pathway.

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