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Extrinsic Wnt signalling controls the polarity component aPKC

Nature Cell Biology volume 9, pages 738–740 (2007)Cite this article

Specification of the axon and dendrites is a critical step in the development of a neuron and requires the asymmetric organization of the cell. A possible link between the extrinsic and intrinsic pathways that drive axon specification has been made with the finding that Dishevelled acts downstream of Wnt5a to activate the PAR6–aPKC–PAR3 pathway.

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Figure 1: Schematic representation of a proposed mechanism for axon specification at the tip of growing axons.

References

  1. Arimura, N. & Kaibuchi, K. Nature Rev. Neurosci. 8, 194–205 (2007).

    Article  CAS  Google Scholar 

  2. Zhang, X. et al. Nature Cell Biol. 9, 743–754 (2007).

    Article  CAS  Google Scholar 

  3. Drubin, D. G. & Nelson, W. J. Cell 84, 335–344 (1996).

    Article  CAS  Google Scholar 

  4. Suzuki, A. & Ohno, S. J. Cell Sci. 119, 979–987 (2006).

    Article  CAS  Google Scholar 

  5. Dotti, C. G. et al. J. Neurosci. 8, 1454–1468 (1988).

    Article  CAS  Google Scholar 

  6. Andersen, S. S. & Bi, G. Q. Bioessays 22, 172–179 (2000).

    Article  CAS  Google Scholar 

  7. Shi, S. H. et al. Cell 112, 63–75 (2003).

    Article  CAS  Google Scholar 

  8. Nishimura, T. et al. Nature Cell Biol. 6, 328–334 (2004).

    Article  CAS  Google Scholar 

  9. Chen, Y. M. et al. Proc. Natl Acad. Sci. USA 103, 8534–8539 (2006).

    Article  CAS  Google Scholar 

  10. Barnes, A. P. et al. Cell 129, 549–563 (2007).

    Article  CAS  Google Scholar 

  11. Wallingford, J. B. & Habas, R. Development 132, 4421–4436 (2005).

    Article  CAS  Google Scholar 

  12. Shi, S. H. et al. Curr. Biol. 14, 2025–2032 (2004).

    Article  CAS  Google Scholar 

  13. Higginbotham, H. R. & Gleeson, J. G. Trends Neurosci. 30, 276–283 (2007).

    Article  CAS  Google Scholar 

  14. Ciani, L. & Salinas, P. C. Nature Rev. Neurosci. 6, 351–362 (2005).

    Article  CAS  Google Scholar 

  15. Rolls, M. M. & Doe, C. Q. Nature Neurosci. 7, 1293–1295 (2004).

    Article  CAS  Google Scholar 

Download references

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  1. Shigeo Ohno is at the Department of Molecular Biology, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan. ohnos@med.yokohama-cu.ac.jp,

    Shigeo Ohno

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  1. Shigeo Ohno
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Ohno, S. Extrinsic Wnt signalling controls the polarity component aPKC. Nat Cell Biol 9, 738–740 (2007). https://doi.org/10.1038/ncb0707-738

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