Daniel Fisher and Marcel Méchali are at the Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France. mechali@igh.cnrs.fr
The ATM and ATR protein kinases are important mediators of the cellular response to DNA damage. They regulate multiple cellular functions as part of a stress response programme, including the activation of cell-cycle checkpoints, DNA replication, DNA repair and DNA recombination. A provocative new study suggests that ATM and ATR also regulate normal DNA replication in unperturbed cells.
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