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Marked for death

Nature Cell Biology volume 10, pages 507–509 (2008)Cite this article

SUMOylation of PML–RARα oncoprotein has been linked to its arsenic-induced degradation and the therapeutic response in acute promyelocytic leukaemia. Two groups identify PML as an in vivo target of the RING finger ubiquitin E3 ligase RNF4, which specifically binds polySUMOylated PML and is essential for the arsenic-induced catabolism of both PML and PML–RARα.

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Figure 1: A hypothetical pathway highlighting the role of RNF4 in controlling PML stability in normal cells and in response to ATO-induced PML degradation.

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Authors and Affiliations

  1. Kevin Petrie and Arthur Zelent are in the Section of Haemato-Oncology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. arthur.zelent@icr.ac.uk,

    Kevin Petrie & Arthur Zelent

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Petrie, K., Zelent, A. Marked for death. Nat Cell Biol 10, 507–509 (2008). https://doi.org/10.1038/ncb0508-507

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