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MicroRNAs — keeping cells in formation

Nature Cell Biology volume 10, pages 501–502 (2008)Cite this article

During epithelial–mesenchymal transition (EMT) cells loosen their intercellular contacts and leave the epithelial layer. Three microRNA (miRNA) families modulate EMT upstream of the key cell-adhesion protein E-cadherin, highlighting the potential importance of miRNAs in EMT-dependent processes, such as mesoderm development and tumour metastasis.

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Figure 1: The miR-141, miR-200b and miR-205 families directly regulate repressors of E-cadherin transcription.

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Authors and Affiliations

  1. Eric A. Miska is at the Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. eam29@cam.ac.uk,

    Eric A. Miska

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  1. Eric A. Miska
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Miska, E. MicroRNAs — keeping cells in formation. Nat Cell Biol 10, 501–502 (2008). https://doi.org/10.1038/ncb0508-501

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