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Chromatin and transcription: histones continue to make their marks

Chromatin architecture is modulated by a large number of enzymes, resulting in the proper regulation of transcription, replication, cell cycle progression, DNA repair, recombination and chromosome segregation. The structure, regulation and coordination of these enzymatic activities were the main topics of discussion at The Enzymology of Chromatin and Transcription Keystone Symposium held in Santa Fe, NM (March 10–16, 2003).

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Figure 1: Potential sites of post-translational modification on nucleosomal histones.
Figure 2: Transcriptional elongation by RNAPII on chromatin substrates.

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Jaskelioff, M., Peterson, C. Chromatin and transcription: histones continue to make their marks. Nat Cell Biol 5, 395–399 (2003). https://doi.org/10.1038/ncb0503-395

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