Michela Felberbaum-Corti1, Françoise Gisou Van Der Goot2
& Jean Gruenberg1
1
Michela Felberbaum-Corti and Jean Gruenberg are in the Department of Biochemistry, Sciences II, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland.
jean.gruenberg@biochem.unige.ch
2
Françoise Gisou Van Der Goot is in the Department of Genetics and Microbiology, CMU, 1, rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Some cell-surface receptors activate downstream signal transduction pathways not only from the cell surface but also from endosomes, suggesting that signalling pathways can be regulated by compartmentalization. A further twist is that different internalization routes seem to predetermine whether transforming growth factor (TGF-) receptors will trigger a signalling response or be degraded.
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(TGF-
signalling pathway by ubiquitin-mediated degradation
