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Conspiracy to disarm APC in interphase

Nature Cell Biology volume 4, pages E119–E120 (2002)Cite this article

The anaphase-promoting complex (APC) initiates exit from mitosis by ubiquitinating A- and B-type cyclins, the activating subunits of cyclin-dependent kinase 1 (Cdk1). Subsequently, the APC has to be inactivated to allow the re-accumulation of mitotic cyclins in the next cell cycle. A newly identified inhibitor of the APC, called Emi1 in vertebrates and Rca1 in Drosophila melanogaster, may have an important function in inactivating the APC during interphase.

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Figure 1
Figure 2: A model illustrating how E2F and Emi1 may conspire to increase cyclin A levels at the G1–S transition.

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  1. Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, Vienna, A-1030, Austria

    Hartmut C. Vodermaier & Jan-Michael Peters

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  1. Hartmut C. Vodermaier
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  2. Jan-Michael Peters
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Vodermaier, H., Peters, JM. Conspiracy to disarm APC in interphase. Nat Cell Biol 4, E119–E120 (2002). https://doi.org/10.1038/ncb0502-e119

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