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Sealed with a X

At the onset of mammalian X-chromosome inactivation, the X chromosomes are counted and then a choice is made about which one to inactivate. New findings provide evidence that a transient physical association between X chromosomes in the nucleus might be involved in this process.

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Figure 1: A map of known genes and regulatory elements in the Xic region surrounding the Xist gene.
Figure 2: A timecourse of the events that initiate XCI during ES cell differentiation.

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Morey, C., Bickmore, W. Sealed with a X. Nat Cell Biol 8, 207–209 (2006). https://doi.org/10.1038/ncb0306-207

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