Benjamin L. Timney and Michael P. Rout are in the Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
How do you build a sorting machine that can function with less than half of its sorting components? This problem challenges our understanding of nucleocytoplasmic transport after the finding that yeast can survive with nuclear pore complexes (NPCs) containing only half their original mass of transport-factor-binding domains.
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