Nature Biotechnology22, 863 - 866 (2004)
Published online: 13 June 2004; | doi:10.1038/nbt981
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Daniel G Anderson, Shulamit Levenberg
& Robert Langer
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Correspondence should be addressed to Robert Langer rlanger@mit.edu
Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell−material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
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