Brief Communication abstract
Nature Biotechnology 25, 317 - 318 (2007)
Published online: 25 February 2007 | doi:10.1038/nbt1287
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo
Zack Z Wang1,2,7, Patrick Au3,4,7, Tong Chen2,5,7, Ying Shao2, Laurence M Daheron2,6, Hao Bai1, Melanie Arzigian1, Dai Fukumura3, Rakesh K Jain3 & David T Scadden2,6
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
- Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
- Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
- Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
- Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
- Department of Hematology, Shanghai Huashan Hospital, Fudan University, Shanghai 200040, China.
- Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
- These authors contributed equally to this work.
Correspondence to: Zack Z Wang1,2,7 e-mail: wangz@mmc.org
Correspondence to: Rakesh K Jain3 e-mail: jain@steele.mgh.harvard.edu
Correspondence to: David T Scadden2,6 e-mail: scadden.david@mgh.harvard.edu
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