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A mid-life crisis for aging theory

Nature Biotechnology volume 26, pages 371–374 (2008)Cite this article

From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs—but the sirtuin hypothesis is now coming under fire. Ken Garber reports.

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Figure 1: Hope or hype? A widely publicized 2006 paper reported that resveratrol, a SIRT1 activator, reduced the risk of death by 30% for mice on a high-fat diet, like the one at right.

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Authors and Affiliations

  1. Ann Arbor, Michigan

    Ken Garber

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  1. Ken Garber
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Garber, K. A mid-life crisis for aging theory. Nat Biotechnol 26, 371–374 (2008). https://doi.org/10.1038/nbt0408-371

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