Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fancy footwork in the sequence space shuffle

Recent reports on directed evolution broaden the scope of evolutionary enzyme engineering.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Random circular permutation provides access to some of the riches of sequence space.

Bob Crimi

References

  1. Dennett, D.C. Darwin's Dangerous Idea: Evolution and the Meanings of Life (Simon & Schuster Inc., New York, NY; 1995) p. 109.

    Google Scholar 

  2. Qian, Z. & Lutz, S. J. Am. Chem. Soc. 127, 13466–13467 (2005).

    Article  CAS  Google Scholar 

  3. Peisajovich, S.G., Rockah, L. & Tawfik, D.S. Nat. Genet. 38, 168–174 (2006).

    Article  CAS  Google Scholar 

  4. Park, H.-S. et al. Science 311, 535–538 (2006).

    Article  CAS  Google Scholar 

  5. Drummond, D.A. et al. Proc. Natl. Acad. Sci. USA 102, 5380–5385 (2005).

    Article  CAS  Google Scholar 

  6. Baird, G.S., Zacharias, D.A. & Tsien, R.Y. Proc. Natl. Acad. Sci. USA 96, 11241–11246 (1999).

    Article  CAS  Google Scholar 

  7. Guntas, G., Mansell, T.J., Kim, J.R. & Ostermeier, M. Proc. Natl. Acad. Sci. USA 102, 11224–11229 (2005).

    Article  CAS  Google Scholar 

  8. Dwyer, M.A., Looger, L.L. & Hellinga, H.W. Science 304, 1967–1971 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arnold, F. Fancy footwork in the sequence space shuffle. Nat Biotechnol 24, 328–330 (2006). https://doi.org/10.1038/nbt0306-328

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0306-328

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing